evaluation of 40-bp insertion/deletion polymorphism of mdm2 and the risk of childhood acute lymphoblastic leukemia

conclusions our findings indicated that mdm2 40-bp ins/del polymorphism was not associated with all in our iranian population. further studies with larger sample sizes and diverse ethnicities are required to verify our findings. background the human murine double minute 2 (mdm2), an oncoprotein, is the major negative regulator of p53. objectives the purpose of this study was to evaluate the impact of 40-bp insertion/deletion (ins/del) polymorphism in the promoter of mdm2 and vulnerability to childhood acute lymphocytic leukemia (all) in a sample of iranian population. patients and methods this case-control study was performed on 75 children diagnosed with all and 115 healthy children. the 40-bp ins/del variant was determined by using the polymerase chain reaction method. results our findings showed that neither the overall chi-square comparison of cases and control subjects (x2 = 1.13, p = 0.569) nor the logistic regression analysis (codominant: or = 1.29, 95% ci = 0.59-2.14, p = 0.745, ins/del vs. ins/ins; or = 1.59, 95% ci = 0.59-3.77, p = 0.372, del/del vs. ins/ins, dominant: or = 1.25, 95% ci = 0.69-2.23, p = 0.552, ins/del + del/del vs. ins/ins and recessive: or = 1.51, 95% ci = 0.67-3.43, p = 0.395, del/del vs. ins/ins + ins/del) indicated any association between mdm2 ins/del and all in our population.